中文刊名： 《系统内科学》
英文刊名： Systemic Internal Medicine
国际刊号：
ISSN 3105-6660（印刷版）
ISSN 3105-6679（网络版）
出版模式：金色开放获取（Gold OA）遵循CC BY 4.0协议，全文永久免费开放
CODEN码： XNABBA 
标识符分配机构：美国化学文摘社（Chemical Abstracts Service，CAS）
发行支持：国图集团（China International Book Trading Corporation，CIBTC）
进口备案刊号： G015Z127
出版机构：Macau Sino-Foreign Medical Publishing Limited
出版频率： 双月刊
出版语言： 中文、英文
投稿要求：接受中文投稿（须同时提交英文标题、摘要、关键词、作者单位及姓名）
本刊已获全球多家权威学术数据库收录，致力于推动高质量研究的全球传播，与全球学者携手，共建开放、协作、前瞻的国际学术共同体。
核心定位
《系统内科学》是一本聚焦系统生物学与内科学深度交叉融合的前沿学术期刊。本刊致力于推动系统医学理念在临床实践中的范式性应用，重点探索多组学整合技术、计算建模方法与人工智能在疾病机制解析、诊疗路径优化及预后预测中的创新应用。我们特别倡导融合分子网络分析、临床信息学与循证医学的多维度、跨尺度研究方法，为构建动态、精准的疾病诊疗体系提供坚实的理论支撑与方法学工具。
约稿范围
本刊重点关注以下前沿研究方向：

1. 疾病发生发展的系统生物学机制与网络调控研究

2. 多组学数据整合分析及临床转化应用

3. 计算医学模型与疾病动态模拟研究

4. 精准医疗策略与个体化治疗方案优化

5. 慢性疾病的系统医学管理模式创新

6. 药物重定位与联合用药的系统性优化研究

7. 医疗大数据挖掘与临床智能决策支持系统开发

8. 分子网络扰动与疾病病理生理机制解析

9. 系统药理学与药物基因组学的整合研究

10. 智慧医疗体系与数字健康技术解决方案创新

目标与愿景
本刊旨在建立系统内科学领域的国际权威学术平台，推动系统医学理论与临床实践的深度融合与范式变革。我们致力于构建跨学科、跨国界的协同创新生态，为临床医师、科研人员及医疗技术创新者提供高水平的学术交流与合作平台，促进精准医疗时代的诊疗模式系统性革新，推动临床医学向预测性、预防性、个性化和参与性方向的根本转型。
学术索引计划
本刊为所有录用论文注册国际标准数字对象标识符（DOI），并正系统推进纳入以下全球重要学术数据库与索引体系：

• Science Citation Index Expanded (SCIE)

• MEDLINE/PubMed

• Scopus

• Embase

• DOAJ（开放获取期刊目录）

• Google Scholar

• 百度学术

• 万方数据知识服务平台

• 维普中文期刊服务平台

• 澳门虚拟图书馆

• 龙源期刊网

• 超星学术发现系统

• 长江文库

• 新华网·学术中国

• CNKI中国知网

Chinese Journal Title: Xi Tong Nei Ke Xue (Systemic Internal Medicine)
English Journal Title: Systemic Internal Medicine
International Standard Serial Number (ISSN):
ISSN 3105-6660 (Print)
ISSN 3105-6679 (Online)
Publication Model:
Gold Open Access (Gold OA)
Full texts are permanently freely accessible under the CC BY 4.0 license.
CODEN: XNABBA
Identifier Assigning Agencies:
Chemical Abstracts Service (CAS)
China International Book Trading Corporation (CIBTC)
Import Registration Number: G015Z127
Publisher:
Macau Sino-Foreign Medical Publishing Limited
Publication Frequency: Bimonthly
Publication Languages: Chinese, English
Submission Requirements:
Submissions in Chinese are accepted (must be accompanied by an English title, abstract, keywords, author affiliations, and author names).
Core Positioning
Systemic Internal Medicine is a frontier academic journal dedicated to the deep integration of systems biology and internal medicine. The journal is committed to advancing the paradigmatic application of systems medicine in clinical practice, with a focus on exploring innovative applications of multi-omics integration technologies, computational modeling methods, and artificial intelligence in disease mechanism elucidation, optimization of diagnosis and treatment pathways, and prognosis prediction. We particularly advocate for multidimensional, cross-scale research methodologies that integrate molecular network analysis, clinical informatics, and evidence-based medicine, aiming to provide solid theoretical foundations and methodological tools for constructing dynamic and precise disease diagnosis and treatment systems.
Scope of Contributions
The journal prioritizes submissions in the following cutting-edge research areas:

1. Systems biology mechanisms and network regulation in disease development

2. Integrative analysis of multi-omics data and its clinical translation

3. Computational medical models and dynamic disease simulation studies

4. Precision medicine strategies and optimization of individualized treatment plans

5. Innovative systems medicine management models for chronic diseases

6. Systematic optimization research on drug repurposing and combination therapies

7. Medical big data mining and development of clinical intelligent decision support systems

8. Analysis of molecular network perturbations and disease pathophysiological mechanisms

9. Integrative research in systems pharmacology and pharmacogenomics

10. Innovations in smart healthcare systems and digital health technology solutions

Aims and Vision
The journal aims to establish an internationally authoritative academic platform in the field of systemic internal medicine, promoting the deep integration and paradigmatic transformation of systems medicine theory and clinical practice. We are dedicated to building a cross-disciplinary, transnational collaborative innovation ecosystem, providing a high-level academic exchange and cooperation platform for clinicians, researchers, and healthcare technology innovators, facilitating systematic innovation in diagnosis and treatment models in the era of precision medicine, and advancing the fundamental transition of clinical medicine towards predictive, preventive, personalized, and participatory care.
Academic Indexing Plan
All accepted articles will be assigned an international Digital Object Identifier (DOI). The journal is systematically pursuing inclusion in the following globally important academic databases and indexing systems:

• Science Citation Index Expanded (SCIE)

• MEDLINE/PubMed

• Scopus

• Embase

• DOAJ (Directory of Open Access Journals)

• Google Scholar

• Baidu Scholar

• Wanfang Data Knowledge Service Platform

• VIP Chinese Journal Service Platform

• Macau Virtual Library

• Longyuan Journals

• Chaoxing Academic Discovery System

• Changjiang Library

• Xinhuanet - Academic China

• CNKI (China National Knowledge Infrastructure)